Set in 1933, ten years after the events in the first film, Rick O'Connell (Brendan Fraser) is married to Evelyn (Rachel Weisz) and the couple has settled in London raising their 9-year-old son Alex (Freddie Boath).
When a chain of events finds the corpse of Imhotep (Arnold Vosloo) resurrected in the British Museum, Imhotep walks the earth determined to fulfill his quest for immortality. But another force has also been set loose, one born of the darkest rituals of ancient Egyptian mysticism and even more powerful than Imhotep. When these forces clash, the fate of the world will hang in the balance, sending the O'Connell's on a mission to save the world and their son before it is too late...